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Since the beginning of the national nanotechnology initiative in 1990, the U.S. government through several of its agencies has spent over $21 Billion on nanotechnology research and development, and education. The United Nations adopted its Millennium Development Goals in 2001; some of them were poverty alleviation and access to clean drinking water, global health, environmental sustainability, and development. Leveraging its strengths in micro and nanotechnology research, The University of Ï㽶´«Ã½ Center for Nanoscale Science and Technology (CNST) collaboratory, established in 2001, embarked upon some of these global challenges, by nurturing an innovation-based research and education ecosystem for preparing the next generation workforce and promoting innovation-based entrepreneurship leading to economic development. This talk will provide an overview of these efforts.